Department of Genetics, Harvard Medical School
Paul F. Glenn Center for the Biology of Aging
The Yankner lab is a member of the Paul F. Glenn Center for the Biology of Aging, which is co-directed by Bruce Yankner and David Sinclair. The Glenn Center is dedicated to understanding the mechanisms of normal aging and the development of interventions to delay its onset and progression, thereby extending the healthy years of human life. It is composed of labs and core facilities, and sponsors a bimonthly aging data club and an annual symposium that attracts hundreds of investigators who work in the area of aging biology. There are now several Glenn Centers nationwide; the Harvard Medical School site is the founding center.
Accelerated Medicines Partnership for Alzheimer’s Disease (AMP-AD Consortium)
The Yankner lab is one of 6 groups that comprise the AMP-AD consortium, a partnership of NIH and industry to accelerate the identification of new therapeutic targets and drugs for Alzheimer’s disease. Our part of the project is focused on the systems biology of AD animal models and the integration of this data with transcriptome and epigenetic data from the aging human brain.
Laboratory of Fred Alt, Boston Children’s Hospital
We collaborate with the Alt lab on the role of DNA damage in aging and Alzheimer’s disease. These studies involve genetically engineered mouse models and in vitro analysis of the DNA damage response and genome stability.
Laboratory of George Church, Harvard Medical School
The Yankner and Church laboratories collaborate on a shared NIH grant to generate induced progenitor stem (iPS) cell lines in which genetic variants have been introduced that predispose to Alzheimer’s disease. This project utilizes new approaches to CRISP-Cas9 genome editing and transcriptional regulation.
Laboratory of Monica Colaiacovo, Harvard Medical School
We have a close collaboration with Monica Colaiacovo’s lab on C. elegans as a model of aging and neurodegenerative disorders. Areas of collaboration include the regulation of genome stability and cell-type specific epigenetic profiling in aging worms.
Laboratory of Steve Elledge, Harvard Medical School
We collaborate with the Elledge lab on the role of senescence in the aging of the brain. A recent joint publication showed dramatic induction of the senescence regulators GATA4 and p16 in aging human neurons and glial cells...
Laboratory of Marcia Haigis, Harvard Medical School
Our long-standing collaboration with the Haigis lab focuses on the role of mitochondrial energy metabolism in the aging of the brain using cell culture and animal model systems
Laboratory of Wade Harper, Harvard Medical School
We collaborate with the Harper lab on protomic analysis of models of aging and neurodegenerative diseases. This entails high resolution, focused systems-based proteomics and integrative data analysis with gene expression and clinical data.
Laboratory of Dana Gabuzda, Dana Farber Cancer Institute
We collaborate with the Gabuzda lab on the regulation of neuroinflammatory responses in the aging brain and Alzheimer’s disease.
Laboratory of David Sinclair, Harvard Medical School
David Sinclair and Bruce Yankner co-direct the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. In addition, the Yankner and Sinclair laboratories collaborate on studies of the role of genome stability in the aging process.
Laboratory of Li-Huei Tsai, MIT
We collaborate with the Tsai lab on the analysis of neurons derived from induced progenitor stem cell lines from aged individuals and patients with Alzheimer’s disease. These studies focus on electrophysiological and epigenetic characterization, as well as the transduction of pathological genes in vitro and in vivo.
Laboratory of Junying Yuan, Harvard Medical School
The Yankner and Yuan laboratories have a long-standing collaborative relationship that has focused on the role of apoptosis and autophagy in aging and neurodegenerative disorders.
For a graphical display of coauthors see: